The useful split is content versus mechanics: the wording changes, while opening the field, pasting, submitting, waiting, and moving on remain the same.
Separate variants from workflow
Create the prompt variants in a reviewed list and automate the identical interface steps used to submit and save each result.
Preserve input-output identity
MacroLoop can replay that mechanical path and process prepared prompts. Give each variant an identifier so outputs can be matched back to the correct input.
Expect uneven model responses
Do not assume every response completes at the same speed or quality. Use generous waits and review for refusals, truncation, and duplicated outputs.
THE TAKEAWAY
Label the variants, automate the fixed interface, and keep evaluation separate.